The design and methodology of premature ejaculation interventional studies

The design and methodology of premature ejaculation interventional studies

Large well-designed clinical efficacy and safety randomized clinical trials (RCTs) are required to achieve regulatory approval of new drug treatments. The objective of this article is to make recommendations for the criteria for defining and selecting the clinical trial study population, design and efficacy outcomes measures which comprise ideal premature ejaculation (PE) interventional trial m...

The significance of premature ejaculation

It is an honor to have the opportunity to comment on the article by Koyuncu and colleagues evaluating the possible correlation between intravaginal ejaculato-ry latency time (IELT) and enuresis [1]. Premature ejaculation (PE) is a very common male sexual dysfunction; the prevalence is over 20% in each age group, so there is a need for identification of such patients, as PE leads to personal dis...

The epidemiology of premature ejaculation

Vast advances have occurred over the past decade with regards to understanding the epidemiology, pathophysiology and management of premature ejaculation (PE); however, we still have much to learn about this common sexual problem. As a standardized evidence-based definition of PE has only recently been established, the reported prevalence rates of PE prior to this definition have been difficult ...

History of Premature Ejaculation

The history of premature ejaculation (PE) is a history of contrasting hypotheses, controversial debates among medical specialists and psychologists, many opinions, and ignorant and embarrassed patients, but it is also the history of independently thinking clinicians, and pioneering clinicians and neuroscientists, who all together and throughout the years contributed to a better insight in a syn...

Erectile dysfunction and premature ejaculation